Autocatalytic base editing for RNA-responsive translational control

Autocatalytic base editing for RNA-responsive translational control

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Genetic circuits that control transgene expression in response to pre-defined transcriptional cues would enable the development of smart therapeutics.Here the authors engineer programmable RNA sensors, DART VADARs, ps5 price new jersey in which ADARs autocatalytically convert sten jacket m target hybridization into a translational output, thus amplifying editing by endogenous ADAR via positive feedback and conferring high dynamic range and a small genetic footprint.